biodistribution study japan

I want to pass it on to some doctors in Japan who have no idea about its existence. Copyright 2023 Pandemic Timeline. All Rights Reserved Poynter Institute 2023, The Poynter Institute for Media Studies, Inc. is a non-profit 501(c)3. 8.6. In particular, a Japanese biodistribution study of Pfizer's Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. Angiotensin II through binding to its type 1 receptors exerts pro-inflammatory, vasoconstrictive, and prothrombotic effects, while angiotensin (17) has opposing effects In addition, angiotensin II increases cytoplasmic and mitochondrial ROS generation leading to oxidative stress. Whats more, TrialSite News reports6 that Pfizer documents submitted to the European Medicines Agency [EMA] reveal the company did not follow industry-standard quality management practices during preclinical toxicology studies as key studies did not meet good laboratory practice (GLP)., Neither reproductive toxicity nor genotoxicity (DNA mutation) studies were performed, both of which are considered critical when developing a new drug or vaccine for human use. In related news, Dr. Malcolm Kendrick posted an article11 on his website June 3, 2021, in which he discusses the links between the SARS-CoV-2 spike protein and vasculitis, a medical term referring to inflammation (itis) in your vascular system, which is made up of your heart and blood vessels. "Biodistribution" study of mRNA vaccines. Yet he was 100% correct. Confidential pfizer research document Translated from Japanese to English. I highlighted important points for easier reading. Because the synthetic mRNA in the vaccine has been programmed to instruct your cells to produce an unnatural, genetically engineered spike protein. 2022 Apr 7;10(4):869. doi: 10.3390/biomedicines10040869. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018 in comparison among (a) local or systemic administration product, (b) commercialized or product in clinical phases, (c) biodistribution measurement modalities, (d) clinical phases of development, (e) used animal species and (f) measurement modalities and biodistribution study duration (refer to Supplementary Table1). Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018, Implementation status of clinical biodistribution, Implementation status of clinical biodistribution by formulation in locally administered product group as, Trends of cell quantification using Alu-qPCR methods. Did Pfizer Fail to Perform Industry Standard Animal Testing Prior to Initiation of MRNA Clinical Trials? S1A). Thus, the absence of safety pharmacology studies is endorsed by the CHMP, Committee for Medicinal Products for Human Use. LNP=LipoNanoParticle which carries the mRNA, LC-MS/MS is liquid chromatography with tandem mass spectrometry. (LogOut/ At first glance, this information seems relatively straightforward. 2009 Aug;(144):3-79. eCollection 2020 Sep 11. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal Is there a difference between the spike protein in the virus itself and the spike protein in the vaccines in terms of effects on the body described here? The European Medicine Agency (EMA) is an agency of the European Union (EU) in charge of the Evaluation and Supervison of Medicinal Products. Not believing the outcome of my research, I called for help from my PhD friends at Penn State in the Materials Research Institute. "Biodistribution" study of mRNA vaccines. Total recovery (% of injected dose) of radiolabeled LNP+modRNA outside the injection site was greatest in the liver (up to 21.5%) and was much less in spleen (1.1%), adrenal glands (0.1%) and ovaries (0.1%). When the spike protein interacts with the ACE2 receptor, it can disrupt mitochondrial signaling, thereby inducing the production of reactive oxygen species and oxidative stress. Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of MRNA-1273 Vaccine Recipients. It is important that your sauna is hot enough (around 170 degrees Fahrenheit) and does not have high magnetic or electric fields. Mina R, von Scheven E, Ardoin SP, Eberhard BA, Punaro M, Ilowite N, Hsu J, Klein-Gitelman M, Moorthy LN, Muscal E, Radhakrishna SM, Wagner-Weiner L, Adams M, Blier P, Buckley L, Chalom E, Chdeville G, Eichenfield A, Fish N, Henrickson M, Hersh AO, Hollister R, Jones O, Jung L, Levy D, Lopez-Benitez J, McCurdy D, Miettunen PM, Quintero-del Rio AI, Rothman D, Rullo O, Ruth N, Schanberg LE, Silverman E, Singer NG, Soep J, Syed R, Vogler LB, Yalcindag A, Yildirim-Toruner C, Wallace CA, Brunner HI; Carra SLE Subcommittee. Please send me all info on any new updates. Not believing the outcome of my research, I called for help from my PhD friends at Penn State in the Materials Research Institute. Fact Sheet for Healthcare Providers Administering Vaccine [Pfizer-BioNTech]. We now know spike protein gets into circulation. The study started last September 16, 2020 and the planned end date is March 31, 2022. This is important to understand. What did the initial Pfizer biodistribution studies show? Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. In the current work, we aimed to investigate the impact of formulation type on biodistribution profile . Biodistribution is a method of tracking where compounds of interest travel in an experimental animal or human subject. The EIN for the organization is 59-1630423. Once in your blood circulation, the spike protein binds to platelet receptors and the cells that line your blood vessels. The sections were washed with 50% EtOH (1 min4). There are many different types of vasculitis, including Kawasakis disease, antiphospholipid syndrome, rheumatoid arthritis, scleroderma and Sjogrens disease. 8600 Rockville Pike 2015;43(1):115125. PMC Study Design Go to Resource links provided by the National Library of Medicine MedlinePlus Genetics related topics: Alzheimer disease Women have reported changes in menstruation after taking mRNA vaccines. The biodistribution of BNT162b2 was examined as an alternative marker. SARS-CoV-2which has been shown to cross the blood-brain barrier in mice and cause many kinds of heart, blood vessel, and brain damagehas a spike protein on its surface, allowing the virus to infect our bodies. This is a nonprofit education and research site. Nothing whatsoever on this site is monetized, not even the Amazon links. I therefore claim fair use of materials featured here. To find out what is new, check out the above sidebar item, Recently Modified Posts. New posts are added according to date of event in keeping with the timeline theme, NOT the date when they are created. Material is often added to existing posts as well, as more is learned about an event. To make best use of this site, consider using the tags, categories, and search box. Many posts also have a See also, on this site list. For more details about the purpose and style of this site, please see the About page. Furthermore, in key studies designed to test whether the vaccine remains near the injection site or travels throughout the body, Pfizer did not even use the commercial vaccine (BNT162b2) but instead relied on a surrogate mRNA producing the luciferase protein. The European Medicines Agency (EMA) needs many detailed studies to confirm that a vaccine is safe, provides adequate protection and is of suitable quality. Dr Joseph Mercola Story at-a-glance Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. Pingback: Vaccine Shedding: The Harm for Those Who Choose NOT to be Vaccinated - The Hollywood Conservative, Pingback: Vaccine Shedding: The Harm For Those Who Choose NOT To Be Vaccinated - TruthMatters.biz, Pingback: Breaking News Round Up Continues As The Old Traditional Rite Mass & Sacraments Become Restricted By Pope Francis | Traditional Catholics Emerge, Pingback: A Secular Perspective on Gods Judgment Anonymous, 7/30/21 | pomegranatesandchains, Pingback: LA School District Mandates COVID Jabs for All Students 12 and Older - Vaccine Effects. Other research suggests the SARS-CoV-2 spike protein can have a serious impact on your mitochondrial function, which is imperative for good health, innate immunity and disease prevention of all kinds. Their data clearly showed that the injection site retained the largest concentration of these nanoparticles, but the article omitted this fact. The Japanese biodistribution study of Pfizer's mRNA vaccine has also found that 0.02% and 0.009% of the vaccine administered dose ended up in the brain at 2-hour and 48-hour, respectively: We never knew the spike protein itself was a toxin and was a pathogenic protein. Data were . The greatest mean concentration was found remaining in the injection site at each time point in both sexes. Biodistribution. When administered, COVID-19 vaccines are injected into the shoulder musclenot into the blood. Please Donate so that we can continue to bring you important updates concerning the Covid Virus Pandemic. In a recent interview1 with Alex Pierson (above), Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., dropped a shocking truth bomb that immediately went viral, despite being censored by Google. Careers. As we reported last June 14, Bridle received a copy of a Japanese biodistribution study, which had been withheld from the public, as a result of a freedom of information request made to the Japanese government for data from Pfizer. Parkinsons disease is a prion disease that has been traced back to prions originating in the spleen, that then travel up to the brain via the vagus nerve. It only means the studies are not available on an internet search. ), To determine the biodistribution of the LNP-formulated modRNA, the applicant did study, determined the biodistribution of a surrogate luciferase modRNA formulated with a LNP with identical lipid composition used in BNT162b2 (mouse study), or the biodistribution of a [3H]-Labelled. The CDC states, After the protein piece is made, the cell breaks down the instructions and gets rid of them.** However, a Japanese document of the Pfizer vaccine data showed biodistribution beyond the local injection site, with distribution highest in the ovaries at 48 hours. The results from this study supported many of the results from the biodistribution-only studies. Problems with blood clotting (coagulation) which are also common during COVID-19 disease are also reported. As expected with an mRNA product, the luciferase expression was transient and decreased over time. Bridle explains the study absolutely refutes the premise that the COVID-19 vaccine stays in the shoulder muscle, asserting: The short answeris absolutely not. Using Luciferine to follow biodistribution of a product is common practice. However, a Japanese document of the Pfizer vaccine data showed biodistribution beyond the local injection site, with distribution highest in the ovaries at 48 hours. When an immune response is launched against the spike protein, the virus stops infecting the body. Multifunctional NP-based technologies with diagnostic and therapeutic functions are being developed for in vivo applications. Likewise, research within thescientific community also reveals various cardiovascular and heart problems, bleeding, and clotting when studying the disease in humans. Technically, it is not following the mRNA vaccine itself but following where the LNP container-luciferine goes as a surrogate to understanding where the mRNA may go. , with maximum concentrations observed at 8-48 hours post-dose. Even my doctor, who is against it, could not tell me public sources. Some of the protein will go to the local draining lymph node in order to activate the immune system., Please consider leaving a comment on the FDA petition to revoke the EUA & prevent licensure of the COVID injections. The mouse study used three female BALB-c mice per group and luciferase protein expression was determined by in vivo bioluminescence readouts using an In Vivo Imaging System (IVIS) following injection of the luciferase substrate luciferine. I had the same link as you but now it is not active. No safety pharmacology studies were conducted with BNT162b2. Avoid all vegetable oils and processed foods. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal 2012 Mar;64(3):375-83. doi: 10.1002/acr.21558. The "Japanese biodistribution study," referenced in the online article appears to be a Japanese translation of a Pfizer toxicology and biodistribution study, which shows nothing like what is being claimed. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. (LogOut/ sharing sensitive information, make sure youre on a federal As a public-health body safeguarding medicines in the European Union (EU), EMA only recommends approval of a vaccine for COVID-19 after a thorough evaluation demonstrating the same high . 22 23 24 25 Janssen told The BMJ its covid-19 vaccine leverages the same technology as its Ebola vaccine, which received licensure last June. When in circulation, the spike protein can bind to the receptors that are on our platelets and the cells that line our blood vessels. That same research also establishes that the spike protein alone is almost entirely responsible for damage to the cardiovascular system if circulating in the body. The liver expression is also supportive of the data from the rat PK study and the findings in the rat repeat-dose toxicological study showing reversible liver vacuolation and increased GGT levels. Remember, the research cited by Bridle at the beginning of this article found the spike protein accumulates in the spleen, among other places. Its past time to #RevoketheEUA https://t.co/ZdeHCKXyPb, BREAKING: Dr. Byram Bridle sent me his report: 'Why Parents, Teens, and Children Should Question the COVID-19 Vaccine'He's an Associate Professor of Viral Immunology at the University of Guelph who brought attention to the Pfizer Japanese study. Perhaps the attached study will be helpful to her. According to Kendrick, all of them have two things in common:12. But, as you can see below, unlike Bridle, Politifact neglected to go beyond interviewing someone with such a huge stake in the vaccines success. Pfizer's biodistribution study for Japanese . Thus it appears that SARS-CoV-2 hijacks mitochondrial machinery for its own benefit, including DMV biogenesis. Support responsible news and fact-based information today! SARS coronavirus 2 (SARS-CoV-2) enters cell by attaching to angiotensin converting enzyme 2 (ACE2) receptors on cell surface Following infection, there is internalization and downregulation of ACE2 receptors. On biodistribution profile found remaining in the Vaccine has been programmed to instruct your cells to produce unnatural. Japanese to English Kendrick, all of them have two things in common:12 Vaccine has been programmed instruct... Which are also reported the above sidebar item, Recently Modified posts down the instructions and gets of. Is new, check out the above sidebar item, Recently Modified posts two things in common:12, called! 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For Medicinal Products for Human use please See the about page the purpose and style of this site, using! Is new, check out the above sidebar item, Recently Modified posts new posts are added to. Pfizer Fail to Perform Industry Standard Animal Testing Prior to Initiation of mRNA vaccines there are many different of... Consider using the tags, categories, and search box make best use of featured... I want to pass it on to some doctors in Japan who have no idea about existence! In vivo applications internet search the purpose and style of this site list )... Tandem mass spectrometry Penn State in the Materials research Institute remaining in the Plasma MRNA-1273!, this information seems relatively straightforward with an mRNA product, the absence of safety pharmacology studies is endorsed the...
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